What do dendritic cells target




















Antigenic targeting of the human mannose receptor induces tumor immunity. J Immunol. Glycosidic Tn-based vaccines targeting dermal dendritic cells favor germinal center B-cell development and potent antibody response in the absence of adjuvant. No advantage of cell-penetrating peptides over receptor-specific antibodies in targeting antigen to human dendritic cells for cross-presentation. Identification of a dendritic cell receptor that couples sensing of necrosis to immunity.

The dendritic cell receptor Clec9A binds damaged cells via exposed actin filaments. F-actin is an evolutionarily conserved damage-associated molecular pattern recognized by DNGR-1, a receptor for dead cells. The dendritic cell receptor DNGR-1 controls endocytic handling of necrotic cell antigens to favor cross-priming of CTLs in virus-infected mice.

J Clin Invest. Antigen delivery to plasmacytoid dendritic cells via BST2 induces protective T cell-mediated immunity. Antigen targeting to plasmacytoid dendritic cells via Siglec-H inhibits Th cell-dependent autoimmunity.

E-pub November 14, DOI jimmunol. Characterization of Siglec-H as a novel endocytic receptor expressed on murine plasmacytoid dendritic cell precursors. Interferon-producing cells: on the front line in immune responses against pathogens. Curr Opin Immunol. CD8- dendritic cells and macrophages cross-present poly D,L-lactate-co-glycolate acid microsphere-encapsulated antigen in vivo.

Tumor therapy in mice via antigen targeting to a novel, DC-restricted C-type lectin. Nectin-like protein 2 defines a subset of T-cell zone dendritic cells and is a ligand for class-I-restricted T-cell-associated molecule. J Biol Chem. Novel insights into the relationships between dendritic cell subsets in human and mouse revealed by genome-wide expression profiling.

Genome Biol. The dendritic cell subtype-restricted C-type lectin Clec9A is a target for vaccine enhancement. Human dendritic cell subsets from spleen and blood are similar in phenotype and function but modified by donor health status.

Antigen crosspresentation by human plasmacytoid dendritic cells. Direct proteasome-independent cross-presentation of viral antigen by plasmacytoid dendritic cells on major histocompatibility complex class I. Nat Immunol. Human plasmacytoid dendritic cells phagocytose, process, and present exogenous particulate antigen. Characterization of four conventional dendritic cell subsets in human skin-draining lymph nodes in relation to T-cell activation.

Nucleic acid agonists for Toll-like receptor 7 are defined by the presence of uridine ribonucleotides. CpG oligonucleotides as adjuvants for vaccines targeting infectious diseases. Adv Drug Deliv Rev. Programming the magnitude and persistence of antibody responses with innate immunity. Immunostimulatory DNA-based vaccines induce cytotoxic lymphocyte activity by a T-helper cell-independent mechanism.

Induction of anti-tumor cytotoxic T cell responses through PLGA-nanoparticle mediated antigen delivery. Memory and effector CD8 T-cell responses after nanoparticle vaccination of melanoma patients.

J Immunother. In situ regulation of DC subsets and T cells mediates tumor regression in mice. Sci Transl Med. Binding of oligoguanylate to scavenger receptors is required for oligonucleotides to augment NK cell activity and induce IFN.

J Biochem. The role of the macrophage scavenger receptor in immune stimulation by bacterial DNA and synthetic oligonucleotides. Toll-dependent selection of microbial antigens for presentation by dendritic cells. Human plasmacytoid dendritic cells are unresponsive to bacterial stimulation and require a novel type of cooperation with myeloid dendritic cells for maturation.

Targeting CpG oligonucleotides to the lymph node by nanoparticles elicits efficient antitumoral immunity. Nonmethylated CG motifs packaged into virus-like particles induce protective cytotoxic T cell responses in the absence of systemic side effects. TLR-dependent T cell activation in autoimmunity. Generalized exacerbation of psoriasis associated with imiquimod cream treatment of superficial basal cell carcinomas.

Clin Exp Dermatol. Exploiting lymphatic transport and complement activation in nanoparticle vaccines. Nat Biotechnol. Nanoparticles target distinct dendritic cell populations according to their size. Eur J Immunol. Targeted, needle-free vaccinations in skin using multilayered, densely-packed dissolving microprojection arrays. CD64 expression distinguishes monocyte-derived and conventional dendritic cells and reveals their distinct role during intramuscular immunization.

Optimization of methods to study pulmonary dendritic cell migration reveals distinct capacities of DC subsets to acquire soluble versus particulate antigen.

J Immunol Methods. Nanoparticle conjugation of antigen enhances cytotoxic T-cell responses in pulmonary vaccination. Targeted delivery of Toll-like receptor ligands to human and mouse dendritic cells strongly enhances adjuvanticity. In situ engineering of the lymph node microenvironment via intranodal injection of adjuvant-releasing polymer particles.

Antibody-antigen-adjuvant conjugates enable co-delivery of antigen and adjuvant to dendritic cells in cis but only have partial targeting specificity.

PLoS One. Engineered lentivector targeting of dendritic cells for in vivo immunization. Potent antitumor immunity generated by a CDtargeted adenoviral vaccine. Cancer Res. Targeting dendritic cells with antigen-containing liposomes: a highly effective procedure for induction of antitumor immunity and for tumor immunotherapy. Langerhans cells regulate cutaneous injury by licensing CD8 effector cells recruited to the skin. In vivo targeting of antigens to human dendritic cells through DC-SIGN elicits stimulatory immune responses and inhibits tumor growth in grafted mouse models.

Mol Immunol. Toll-like receptor activation enhances cell-mediated immunity induced by an antibody vaccine targeting human dendritic cells. J Transl Med. Breast Cancer Res. In vivo targeting of dendritic cells for activation of cellular immunity using vaccine carriers based on pH-responsive microparticles.

Int J Pharm. Design of neo-glycoconjugates that target the mannose receptor and enhance TLR-independent cross-presentation and Th1 polarization. FEBS Lett. Enhanced delivery of immunoliposomes to human dendritic cells by targeting the multilectin receptor DEC Scand J Immunol. Cancer Biol Ther. CDtargeted adenoviral gene transfer to dendritic cells through the use of a novel bispecific single-chain Fv antibody enhances cytotoxic T cell activation.

Genetically targeted adenovirus vector directed to CDexpressing cells. J Virol. Add comment Close comment form modal. Submit a comment. MacLennan CM, et al. T helper 1 Th1 and Th2 characteristics start to develop during T cell priming and are associated with an immediate ability to induce immunoglobulin class switching.

Mosmann TR, Coffman R. TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu Rev Immunol. Cytokine-secreting follicular T cells shape the antibody repertoire.

Protective neutralizing influenza antibody response in the absence of T follicular helper cells. Collins AM. IgG subclass co-expression brings harmony to the quartet model of murine IgG function. Nimmerjahn F, Ravetch JV. Fcgamma receptors: old friends and new family members. Nat Med. Broadly neutralizing anti-HIV-1 antibodies require Fc effector functions for in vivo activity. Broadly neutralizing hemagglutinin stalk-specific antibodies require FcgammaR interactions for protection against influenza virus in vivo.

Broadly neutralizing anti-influenza antibodies require Fc receptor engagement for in vivo protection. J Clin Invest. Universal vaccine against influenza virus: linking TLR signaling to anti-viral protection.

Hierarchical and redundant roles of activating FcgammaRs in protection against influenza disease by M2e-specific IgG1 and IgG2a antibodies. Sci Transl Med. J Biol Chem. Targeting antigen to mouse dendritic cells via Clec9A induces potent CD4 T cell responses biased toward a follicular helper phenotype.

Extrafollicular B cell activation by marginal zone dendritic cells drives T cell—dependent antibody responses. Immunol Lett. Targeting of LcrV virulence protein from Yersinia pestis to dendritic cells protects mice against pneumonic plague. Unsupervised high-dimensional analysis aligns dendritic cells across tissues and species. Human lymphoid organ dendritic cell identity is predominantly dictated by ontogeny, not tissue microenvironment.

Dendritic cell targeted Ccl3- and Xcl1-fusion DNA vaccines differ in induced immune responses and optimal delivery site. Sci Rep. CD64 expression distinguishes monocyte-derived and conventional dendritic cells and reveals their distinct role during intramuscular immunization. Steinman RM. Decisions about dendritic cells: past, present, and future. Georgetown, TX: Landes Bioscience, Google Scholar.

B cell-intrinsic MyD88 signaling controls IFN-gamma-mediated early IgG2c class switching in mice in response to a particulate adjuvant. Eur Immunol J. Enhancing vaccine antibody responses by targeting Clec9A on dendritic cells. NPJ Vacc. Targeting antigen to Clec9A primes follicular Th cell memory responses capable of robust recall.

Ligation of CD11c during vaccination promotes germinal centre induction and robust humoral responses without adjuvant. Targeting antigens to CD rapidly induces antigen-specific IgG, affinity maturation, and immunological memory.

Enhanced germinal center reaction by targeting vaccine antigen to major histocompatibility complex class II molecules. NPJ Vaccines. Sustained antigen availability during germinal center initiation enhances antibody responses to vaccination. Murine antibody responses to cleaved soluble HIV-1 envelope trimers are highly restricted in specificity. Elicitation of robust tier 2 neutralizing antibody responses in nonhuman primates by HIV envelope trimer immunization using optimized approaches.

Slow delivery immunization enhances HIV neutralizing antibody and germinal center responses via modulation of immunodominance. Cirelli KM, Crotty S. Germinal center enhancement by extended antigen availability. Curr Opin Immunol. Endocytosis deficient murine Xcl1-fusion vaccine enhances protective antibody responses in mice.

Extrafollicular activation of lymph node B cells by antigen-bearing dendritic cells. The dendritic cell subtype-restricted C-type lectin Clec9A is a target for vaccine enhancement. Identification of a dendritic cell receptor that couples sensing of necrosis to immunity. Int Immunol. Similar antigen cross-presentation capacity and phagocytic functions in all freshly isolated human lymphoid organ-resident dendritic cells. A comparative study of the T cell stimulatory and polarizing capacity of human primary blood dendritic cell subsets.

Mediators Inflamm. Antibodies targeting Clec9A promote strong humoral immunity without adjuvant in mice and non-human primates. The anti-influenza M2e antibody response is promoted by XCR1 targeting in pig skin. Antigen targeting to dendritic cells elicits long-lived T cell help for antibody responses. Trumpfheller, C. Bozzacco, L. Mahnke, K. The dendritic cell receptor for endocytosis, DEC, can recycle and enhance antigen presentation via major histocompatibility complex class II-positive lysosomal compartments.

Cell Biol. Hawiger D. Dendritic cells induce peripheral T cell unresponsiveness under steady state conditions in vivo. J Exp Med , —79 Gurer, C. Targeting the nuclear antigen 1 of Epstein-Barr virus to the human endocytic receptor DEC stimulates protective T-cell responses. Blood , —9 Targeting of LcrV virulence protein from Yersinia pestis to dendritic cells protects mice against pneumonic plague. Do, Y. Vaccine 30 , —67 Targeting of antigens to activated dendritic cells in vivo cures metastatic melanoma in mice.

Cancer Res. Johnson, T. Inhibition of melanoma growth by targeting of antigen to dendritic cells via an anti-DEC single-chain fragment variable molecule. Coffman, R. Mechanism and regulation of immunoglobulin isotype switching. Advances in Immunology 54 , —70 Frese, M.

Interferon-gamma inhibits replication of subgenomic and genomic hepatitis C virus RNAs. Hepatology 35 , — Stabenow, D. Bioluminescence imaging allows measuring CD8 T cell function in the liver.

Hepatology 51 , —7 Thimme, R. Determinants of viral clearance and persistence during acute hepatitis C virus infection. Liu, C. Hepatology 37 , —42 Wille-Reece, U. USA , —4 Neumann, A. Hepatitis C viral dynamics in vivo and the antiviral efficacy of interferon-alpha therapy.

Science , —7 Flamar, A. Noncovalent assembly of anti-dendritic cell antibodies and antigens for evoking immune responses in vitro and in vivo. Idoyaga, J. USA , —9 Cazorla, S. Prime-boost immunization with cruzipain co-administered with MALP-2 triggers a protective immune response able to decrease parasite burden and tissue injury in an experimental Trypanosoma cruzi infection model. Vaccine 26 , — Knothe, S. Immunobiology , —7 Pandey, S.

Pegylated bisacycloxypropylcysteine, a diacylated lipopeptide ligand of TLR6, plays a host-protective role against experimental Leishmania major infection. Gurramkonda, C. Purification of hepatitis B surface antigen virus-like particles from recombinant Pichia pastoris and in vivo analysis of their immunogenic properties. B Analyt. Life Sci. Schulze, K. A prime-boost vaccination protocol optimizes immune responses against the nucleocapsid protein of the SARS coronavirus. Vaccine 26 , —84 Doherty, P.

T-cell-mediated immunopathology in viral infections. Moskophidis, D. Spengler, U. Between Scylla and Charybdis: the role of the human immune system in the pathogenesis of hepatitis C. World J. Schmitz, V. Induction of murine liver damage by overexpression of CD40 ligand provides an experimental model to study fulminant hepatic failure.

Hepatology 44 , —9 Steinhagen, F. TLR-based immune adjuvants. Vaccine 29 , —55 Flynn, B. Immunization with HIV Gag targeted to dendritic cells followed by recombinant New York vaccinia virus induces robust T-cell immunity in nonhuman primates.

Dendritic cell-targeted protein vaccines: a novel approach to induce T-cell immunity. J Intern Med. Ruane, D. A dendritic cell targeted vaccine induces long-term HIV-specific immunity within the gastrointestinal tract. Mucosal Immunol. Stahl-Hennig, C. Synthetic double-stranded RNAs are adjuvants for the induction of T helper 1 and humoral immune responses to human papillomavirus in rhesus macaques.

PLoS Pathog. Caskey, M. Synthetic double-stranded RNA induces innate immune responses similar to a live viral vaccine in humans.

J Exp Med. Morse, M. Phase I study utilizing a novel antigen-presenting cell-targeted vaccine with Toll-like receptor stimulation to induce immunity to self-antigens in cancer patients. Clin Cancer Res.



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